Denamarin is a liver supplement for dogs or cats containing S-Adenosylmethionine (SAMe) and silybin. Supporting the liver is essential to improve liver function. Administering SAMe, which is found in Denamarin, has been shown to increase liver glutathione, a potent antioxidant formed when cats and dogs metabolize SAMe. The SAMe in Denamarin has also been shown to help protect liver cells from cell death and may help cell repair and regeneration. Denamarin also helps support your pet's liver through the administration of silybin, which is the most active part of an extract from milk thistle known as silymarin. Silybin/silymarin has been shown to support liver function by acting as an antioxidant that stimulates the flow of bile through the liver to aid in the digestion and absorption of nutrients from your pet's diet. Silybin also helps with liver cell regeneration and enhance levels of glutathione, the liver's major detoxifying agent.